is an interactive
program, written by
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. Hex understands protein and DNA structures in
Hex will run on most Windows-XP , Linux and Mac OS X PCs. The recent versions now include CUDA support for Nvidia GPUs . On a modern workstation, docking times range from a few minutes or less when the search is constrained to known binding sites, to about half an hour for a blind global search (or just a few seconds with CUDA) . On multi-processor Linux systems, docking calculation times can be reduced in almost direct proportion to the number of CPUs and GPUs used. The calculations can be accelerated by using an optional disc cache (strongly recommended) of about 1 GB of disc space.Windows-XP Linux Mac OS X now include CUDA support for Nvidia GPUs (or just a few seconds with CUDA)
For Academic and Governmental users, a runtime version of Hex may be downloaded free of charge. You are asked only to comply with a wordy, but mostly harmless, licence agreement. Corporate users may also download the software for evaluation, although prior agreement with the author is required if the program is to be used for profit.
The User Manual is included in the software installation, and is also available here:
The basic installation includes some examples. A more extensive set of docking test cases can be obtained from Zhiping Weng's
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If you wish to try
without downloading the actual program, please use the link below to access the on-line docking server. With our new GPU-based code, a typical docking job takes about
15 seconds on our server.
The "Sam" (symmetry assembler) program uses the Hex polar Fourier correlation technique to build symmetrical protein complexes with any of the naturally occurring point group symmetries (Cn, Dn, T, O, and I). Check it out!
KBDOCK is a database of all known structural domain-domain interaction, built directly from the PDB and Pfam (2013 snapshots). If structural homologues exist for your docking target, KBDOCK might be able to help! If KBDOCK finds homology templates, it can also be used as a handy way to launch a docking job with HexServer.
INDIANAPOLIS, Ind.– Looking for a fun new place to sled in Indy? Look no further.
Here are some of the best sledding spots around town:
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: 11300 E. Prospect St., Indianapolis
You can see this hill at Paul Ruster Park from the street. It’s huge. The hill has plenty of room for a lot of sledders and the hill has a nice view from the top. The little ones might need some help climbing to the very top! The hill also has a homemade ramp at the bottom.
Koteewi Run Seasonal Slopes : 11800 Koteewi Drive, NoblesvilleKoteewi Run Seasonal Slopes
This 700-foot hill is specifically meant for snow tubing. Koteewi Run has groomed lanes and custom snow tubes. Sledders simply ride on the tow line to get back to the top for another run.Koteewi Run is part of theStrawtown Koteewi Parkdevelopment being built by theHamilton County, Indiana Parks Recreation Department.
Hours: Monday-Thursday, 1 p.m.-9 p.m., Friday, 1 p.m.-10 p.m., Saturday, 10 a.m.-12 a.m., Sunday, 10 a.m.-10 p.m.
Tickets: $25 and up.
Southeastway Park : 5624 S. Carroll Rd., New PalestineSoutheastway Park :
This hill is a hidden gem in New Palestine. The hill is tall and wide, which allows sledders more room as they walk up and down the hill. The park has beautiful scenery and the area with the hill is free of trees.
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: 8015 Bluff Road., Indianapolis
This is the go-to spot for people who live on the south side of Indy. The park has a wide variety of slopes for the entire family to enjoy!
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:6000 N. Post Road, Indianapolis
Fort Harrison features one of the biggest sledding hills in the area with amazing views.
$7 entrance fee.
Holliday Park : 6363 Spring Mill Rd., IndianapolisHolliday Park
The slopes at Holliday Park are tucked away behind the nature center. There are a few different options for slopes. Sledding at Holliday Park would be great for younger children.
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: 1001 S. Belmont Ave, Indianapolis
That’s why we created
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When you’re using an app to create a symmetrical image, there are a few things to look out for which may cause problems in the final image.
If clouds in the sky aren’t horizontal, they’ll make unnatural shapes when they meet in the middle. The same thing happens with waves in water, rocks, trees and just about anyother objectsyou can think of.
Here’s an example of problem areas to look out for when using apps like Sparkmode to create your symmetrical images. The angled clouds coming together look unnatural and the rocks being squished together make some weird shapes.
This is an example of finding the right point to mirror the image in the Sparkmode app. If I were to slide the original image to the left or right a little bit, the tree at the top of the island would have two tops and look unnatural. I had to find the sweet spot where it looked like a normal tree.
Another issues that may arise when creating a symmetrical image in an app is problems with shadows. The shadows in the image above are not all falling in the same direction which doesn’t make sense to our eye.
When creating symmetrical images using apps, be mindful of everything around your lines of symmetry and watch out for unnatural or strange shapes being caused by the mirrored objects.
One final point… Try not to get stuck only seeing the world in symmetry or you’ll miss out on other photo opportunities.
After you take a photo with your symmetrical composition, be sure to move around and take a few asymmetrical shots as well. This will add variety to your photos and show your subject or scene from different viewpoints.
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Free Video Reveals... 7 Hidden iPhone Camera Features That Every Photographer Should UseJoin Over 250,000 EU Immigration and Asylum Law and Policy
23 Friday Mar 2018
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By Nula Frei , PhD, Senior Researcher, Institute of European Law, University of Fribourg Constantin Hruschka , Max Planck Institute for Social Law and Social Policy, Munich
As a reaction to the “unprecedented migratory flows”, the EU Commission issued a
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on 7 June 2016. The EU Partnership Framework essentially unites all actions of the EU Member States (individually and collectively) to combat smuggling and trafficking, to address “the fate of migrants and refugees” as well as to manage migration “in a sustainable way” and to fight against deaths at sea.
As part of the actions under the new Partnership Framework, measures to prevent irregular migration and irregular entries play a primary role ( alongside with “fast and operational returns” and “specific and measurable increases in the number and rate of return and readmission” ). These measures always take place in a legal grey zone, threatening to conflict with the obligations arising from international and European law and especially the prohibition of refoulement. While the European Court of Human Rights (ECtHR) has already provided a legal compass for measures at the borders and under the control of European states (see following paragraph), such guidance lacks for cooperation with third countries. The following article aims to provide such legal orientation, using the example of the central Mediterranean route.
Continue reading »
09 Friday Mar 2018
By Daniel Thym, Universität KonstanzDaniel Thym,
Last year‘s general election was a game changer in German politics. The ‘grand coalition’ of Christian and Social Democrats, which had governed the federal republic from 2005-09 and 2013-17, lost considerably and won no less than 53.5 % of the vote (33 % for the CDU/CSU; 20.5% for the SPD). Moreover, a populist right-wing party entered the German Bundestag for the first time: the Alternative für Deutschland AfD which gained 12.6 % last September and continues to do well in opinion polls.
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AMD can now use the latest Clover again r4428 thanks to Slice who fixed it.
Our Facebook page - https://www. facebook.com/AMDOSX/
AMD High Sierra kernel updated to 10.13.3 sources - https:// forum.amd-osx.com/viewtopic.php? p=28309#p28309 …
A community focused on the development and support for AMD CPUs on OS X.
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